►▼Annual meeting of the physical society of the republic of China 2016; Liu L.-C., C.-Y. Song, Z.-R. Lin, Y.-C. Lin, A. Karmenyan, S. Norina, O. Levinson, B. Zousman, E. Perevedentseva, C.-L. Cheng; Characterization of magnetic-modified diamond nanoparticlesfor targeted drug delivery (January 2016)
Abstract
Recently nanodiamond (ND) bio-applications are widely discussed and developed due to ND’s physical-chemical properties (surface, structure, spectroscopic) and bio-compatibility [1], convenient particularly, for drug and gene delivery [2], for bio-imaging [1], delivery tracing [3], sensing and biological processes visualization [4], etc. Using ND helps in solving the problems of targeted drug delivery, utilizing the possibilities of multifunctional surface modification [5]; pH-dependent release, regulating Cl- ion concentration [6], etc. On the other hand, among the physical methods to control delivery of nanoparticles magnetic methods are developed and look highly promising [7].New developed particles of magnetic-modified ND (RayND-M) join advantages of ND and magnetic nanoparticles. In this work we characterize and analyze the RayND-M properties and discuss perspectives of their targeted delivery in biological system for bio-applications.
The particles morphology and size were analyzed using SEM imaging, and measurements by Dynamic Light Scattering (DLS) method and aggregation has been estimated; the particles composition and structure have been revealed by Energy Dispersive Spectroscopy (EDS) and Raman spectroscopy. Surface properties and their suitability for conjugation with molecules of interests were studied using infra-red spectroscopy (FTIR) and -potential measurements by DLS method. Fluorescence spectra of the RayND-M have been measured using excitations with CW lasers with wavelengths 488, 532 and pulse laser with excitation wavelength 800 nm. Well-detectable signal has been observed both at one-photon and two-photon excitation, as well as at analysis of the RayND-M fluorescence lifetime. The origins of fluorescence in RayND-M are discussed. Together with observation of RayND-M low cytotoxicity these properties make these particles promising for imaging applications with wide variety of excitation and detection conditions.
Magnetic properties and motility of RayND-M in non-homogenious magnetic field are discussed from point of view of controllable transport in biological object. Additionally, other possibilities to utilize magnetism of the diamond nanoparticles in the biological studies and theranostic purposes are considered.
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Poster: Magnetic nanodiamonds for drug delivery